Seventeen-year-old Juliette Ferrars is the protagonist and first-person narrator of Unravel Me. After spending many years in psychiatric facilities because of her power of lethal touch, Juliette struggles with the aftermath of the isolation she experienced during her incarceration. Juliette is prone to self-hatred and has thoughts of suicide that stem from long being told she is a “monster” by her parents and other authority figures throughout her childhood and adolescence. Juliette fears her own powers and begins the novel with a strong attachment to her boyfriend, Adam Kent, with whom she associates to the exclusion of all others. Juliette craves physical touch even as she fears the repercussions of what her lethal touch powers may do to others, and this ever-present conflict means her physical encounters with Adam are always laced with guilt.

Over the course of Unravel Me, Juliette gradually learns to become more confident. This journey is helped in part due to her increasing friendships with other members of Omega Point, notably Kenji. The training she undergoes to improve control over her powers (which Juliette learns in this book, include super strength) also helps Juliette become less fearful. This leads to her paying less attention to her emotional concerns and being more involved in the conflict with The Reestablishment.